Tadalafil vs Sildenafil: What is the Difference?
Erectile Dysfunction is one of the major medical conditions faced by people nowadays. The generic drugs are commonly the PDE-5 inhibitors that are used to treating Erectile Dysfunction in a man. Generic Drugs containing Tadalafil vs Sildenafil are compared with each other from time to time.
Comparing Tadalafil and Sildenafil:
Both these drugs are known to be a phosphodiesterase-5 inhibitor and are used extensively to treat Erectile Dysfunction. Both these drugs come with some side effects which include things like headaches, flushing of the skin, chest pain, pain in the muscles, dizziness, blurry vision, diarrhea, loss of hearing, a prolonged erection. The hardness of the penis stays for 18 hours in case of Tadalafil and Sildenafil stays in the system for about 4 to 6 hours.
How is erection caused?
Erection is caused because of the blood flow that goes to the penis. When a person is sexually stimulated under normal circumstances nitric oxide is released which releases an enzyme called guanylate cyclase.
This enzyme helps in the production of cyclic guanosine monophosphate. CGMP is responsible for increasing the flow of blood that goes to the penis and helps in releasing the pressure as and when a person is done with sex.
Both Sildenafil and Tadalafil works by inhibiting an enzyme called phosphodiesterase 5. This enzyme usually destroys cGMP and by preventing that from happening, cGMP works by keeping the erection of a person persistent and for a longer period of time.
Side effects caused by Sildenafil and Tadalafil
Some of the common side effects caused by Tadalafil are listed below:
- Flushing of the face
- Upset stomach
- Low blood pressure
- Abnormalities in the ejaculation process
- Change in the vision
Side effects caused by Sildenafil are listed below:
Around 15% of the population suffer from the side effects of this drug.
- Congestion in the nose
- Flushing of the skin
- Pain in the stomach
- Rashes on the skin
- Urinary Tract Infections
- Change in the vision of a person
The difference in the dosage of both the medicines
Tadalafil: The initial dosage of the drug Tadalafil goes up to 10 mg per day and is taken before getting involved in sexual activity. This dosage is then subsequently increased from 10 mg to 20 mg if everything works fine and can even be pushed down to 5 mg per day.
Once this drug is taken, its effect lasts for up to 36 hours a day. The dosage of this medicine should not be doubled within 72 hours of taking this drug. For people who take this medicine for Erectile Dysfunction and BPH, the dosage of 5mg is recommended on a daily basis.
For patients who suffer from liver and kidney functions, the dosage needs to be adjusted in that case.
Sildenafil: The initial recommended dosage of the medicine goes from 25mg to 100mg and should be taken an hour before starting sexual activity. The maximum dosage of this drug should not be exceeded for more than 100mg per day. People who are aged 65 years of age should start with a minimal dosage of 25 mg.
The working mechanism of Sildenafil acts really fast because of the rapid absorption process. Having this medicine post a fatty meal can reduce the absorption process of this medicine which may delay the acting concentration of this medicine.
What is Tadalafil?
The drug Tadalafil is a generic name of the drug Cialis and works by taking a lower dosage of this medicine on a daily basis. This drug allows a person to get an erection at any time of the day and stays effective in the system for about 36 hours. The effect of this medicine starts to kick in after 15 to 20 minutes.
What Is Sildenafil?
The drug Sildenafil is a generic version of the drug Viagra. Viagra is known to be one of the best-known treatments for the medical condition Erectile Dysfunction. This drug has been licensed for use for over 15 years now and there are millions of people who depend on this medicine. Since Sildenafil is a generic form of the drug Viagra, its price is much cheaper in comparison to the brand Viagra
The working mechanism of drug Tadalafil?
Tadalafil is a PDE-5 inhibitor that works by relaxing the muscles. This, in turn, enables the flow of blood into the penis which makes way for erection. This drug does not work by increasing the sexual desires of a person but helps in treating the physical problems that are associated with people getting an erection.
Is the working mechanism of Tadalafil quicker than Sildenafil?
The onset of action of both the drugs is really fast but if we compare both of them, Tadalafil tends to be faster than the drug Sildenafil. The drug Sildenafil takes about 30 minutes to kick in while as Tadalafil works after 15 minutes of consuming it. Tadalafil is dosed daily for a person which enables a man to achieve an erection at any part of the day.
What drug lasts longer, Tadalafil or Sildenafil?
The duration of action of the drug Tadalafil is longer in comparison to Sildenafil. Tadalafil stays in the body of a person for up to 36 hours and is also known by another name called The Weekend Pill.
This gives the benefit to a person as they don’t need to pre-plan the dosage before the expected sexual activity. The effect of the medicine stays in the system for more than 12 hours and is sometimes known to act even after 36 hours of taking this medicine.
What drug is more effective, Tadalafil or Sildenafil?
Both these drugs are known for their high success rates. These drugs have helped men in regaining their sexual life. Both these medicines in one clinical trial were supposed to improve the condition of erection for 81 and 82 percent of patients for Tadalafil and Sildenafil respectively. Both these drugs are known to be effective and do not hold any difference when it comes to delivering the results.
What drug has minimal side effects?
The working mechanism of both drugs work in the same way and that is why they both share the same set of side effects. These side effects are:
- Flushing of the face
It has been noticed that Sildenafil has some other side effects that have not been seen in patients who take Tadalafil. They include:
- Rashes on the skin
- Visual Disturbance
When it comes to side effects, tadalafil shows fewer side effects.
If we conclude the observation on both of them, we can say that Tadalafil is a modern drug that treats Erectile Dysfunction in a better way with fewer side effects and quicker onset of action.
There are many advantages offered by Tadalafil in comparison to Sildenafil. Also, the time for how long Tadalafil stays effective in the system is more in comparison with Sildenafil.